' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 17 Researches
8.1
USERS' SCORE
Excellent
Based on 26 Reviews
9
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%
Top Medical Research Studies
9
Vitamin D3 improves back pain
Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial.
Direct effect on back pain
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Read More
7
Vitamin D3 and low back pain
Lower serum 25-hydroxyvitamin D3 concentration is associated with higher pain and disability in subjects with low back pain: a case-control study.
Highlights vitamin D3's importance
We conducted a study to explore the connection between vitamin D3 levels and the impact of low back pain (LBP) on function and pain levels among a group of middle-aged Azeri individuals in North West Iran. Our case-control approach included 63 patients suffering from LBP and 55 healthy participants.
By analyzing blood samples, we found that the average serum concentration of 25-hydroxyvitamin D3 was notably lower in the LBP group compared to the healthy controls. This suggests that those with lower vitamin D levels are more likely to experience LBP.
Moreover, our analysis revealed a significant relationship between vitamin D3 levels and both pain intensity and disability. Specifically, we noted that lower vitamin D levels correlated with higher pain intensity as measured by a Visual Analogue Scale and greater functional disability assessed with the Modified Oswestry Questionnaire.
Overall, our findings highlight the potential role of vitamin D3 in managing back pain and suggest that addressing vitamin D deficiency could help improve outcomes for individuals suffering from LBP.
By analyzing blood samples, we found that the average serum concentration of 25-hydroxyvitamin D3 was notably lower in the LBP group compared to the healthy controls. This suggests that those with lower vitamin D levels are more likely to experience LBP.
Moreover, our analysis revealed a significant relationship between vitamin D3 levels and both pain intensity and disability. Specifically, we noted that lower vitamin D levels correlated with higher pain intensity as measured by a Visual Analogue Scale and greater functional disability assessed with the Modified Oswestry Questionnaire.
Overall, our findings highlight the potential role of vitamin D3 in managing back pain and suggest that addressing vitamin D deficiency could help improve outcomes for individuals suffering from LBP.
Read More
7
Vitamin D3 may reduce back pain
Vitamin D supplementation may improve back pain disability in vitamin D deficient and overweight or obese adults.
Highly relevant to vitamin D3 effects
We explored the potential benefits of vitamin D3 supplementation for alleviating back pain in overweight or obese adults who were also vitamin D deficient. In a controlled study, 65 participants with a body mass index (BMI) of 25 or higher and low vitamin D levels received either a high dose of vitamin D3 or a placebo for 16 weeks.
After the treatment, we found that while vitamin D levels significantly increased in those taking the supplement, there were no overall significant differences in back pain intensity or disability scores between the vitamin D group and the placebo group.
However, it was noteworthy that among participants whose vitamin D levels were particularly low—under 30 nmol/L—those taking vitamin D did experience a meaningful reduction in back pain disability compared to those receiving placebo. This indicates that addressing severe vitamin D deficiency might not only support bone health but also improve the quality of life for those suffering from back pain—especially in overweight individuals.
These insights invite consideration for regular vitamin D testing in this demographic, offering a potential pathway to managing back pain more effectively.
After the treatment, we found that while vitamin D levels significantly increased in those taking the supplement, there were no overall significant differences in back pain intensity or disability scores between the vitamin D group and the placebo group.
However, it was noteworthy that among participants whose vitamin D levels were particularly low—under 30 nmol/L—those taking vitamin D did experience a meaningful reduction in back pain disability compared to those receiving placebo. This indicates that addressing severe vitamin D deficiency might not only support bone health but also improve the quality of life for those suffering from back pain—especially in overweight individuals.
These insights invite consideration for regular vitamin D testing in this demographic, offering a potential pathway to managing back pain more effectively.
Read More
Most Useful Reviews
9.5
Reduced back pain
I recommend this to anyone lacking calcium. The price-to-quality ratio is good, and I did not experience any aftertaste or side effects. My back pain has significantly decreased in the morning, especially with my osteochondrosis.
Read More
9.5
Back pain relief
I ordered this calcium supplement on a whim due to the price. To my surprise, after two weeks, my shoulder pain, from which I suffered greatly, disappeared, even with arthrosis. I highly recommend it; it truly works!
Read More
8.3
Reduced back pain
I purchased this for my husband to relieve his back pain from osteochondrosis. He experienced no side effects and found it good value for money, significantly reducing his pain.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 17 Researches
8.1
9.5
Pregnancy osteoporosis therapy outcomes
Successful neridronate therapy in pregnancy-associated osteoporosis.
Combined treatment limits isolation
We observed a rare condition known as pregnancy-associated osteoporosis, which affected a 38-year-old woman after she gave birth. Just a month postpartum, she experienced sudden back pain due to four vertebral fractures, and her bone density was notably low, especially in the spine.
While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.
Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
While the patient's biochemical tests were largely normal, we noted some concerning markers, including elevated urinary deoxypyridinoline and slightly reduced levels of serum vitamin D3. To address her symptoms and improve her bone health, a combination therapy consisting of neridronate, calcium, and cholecalciferol (vitamin D3) was initiated.
Encouragingly, after one month on this treatment, she reported being pain-free. Moreover, a follow-up bone density scan after six months indicated a significant improvement in her bone density in both the spine and hip areas. This suggests that while neridronate played a crucial role, it's also important to recognize the potential benefits of vitamin D3 within this treatment regimen. However, since the effects were part of a combination therapy, we cannot isolate the specific impact of vitamin D3 on back pain alone.
Read More
9.5
PLO treatment and vitamin D3
Effective treatment of severe pregnancy and lactation-related osteoporosis with teriparatide: case report and review of the literature.
Vitamin D3's role is unclear
We explored the impact of various treatments, including vitamin D3, on severe back pain caused by pregnancy-related osteoporosis (PLO). In a significant case study, a 23-year-old woman experiencing debilitating back pain was treated after her first childbirth. By monitoring her bone mineral density, we noted low T- and Z-scores in her lumbar spine.
The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.
Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
The treatment plan included teriparatide, calcium, and vitamin D3. While we observed substantial improvements in bone density and relief from pain, it’s important to note that the isolated effect of vitamin D3 is difficult to pinpoint due to its combination with other treatments.
Overall, while vitamin D3 plays a notable role alongside teriparatide in managing back pain linked to PLO, its individual effectiveness remains somewhat unclear.
Read More
9
Denosumab improves back pain outcomes
Effectiveness of denosumab on back pain-related disability and quality-of-life in patients with vertebral fragility fractures.
Difficulty isolating vitamin D3 impact
We explored the effectiveness of denosumab on alleviating back pain and enhancing quality of life in post-menopausal women suffering from vertebral fractures. This study, involving 140 women aged around 70, assessed participants who received denosumab alongside calcium and vitamin D3 for a year.
While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.
The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
While treatment with denosumab led to significant improvements in back pain disability, overall physical and mental health quality metrics, including the Spine Pain Index and the EuroQol-5D scale, were markedly more effective post-treatment.
The ongoing role of vitamin D3 remains obscured, as it was part of a combined regimen that made it challenging to isolate its individual effects on back pain. Thus, while we observed clear benefits from the denosumab treatment, the unique contribution of vitamin D3 to back pain relief requires further investigation.
Read More
9
Vitamin D3 improves back pain
Vitamin D Supplementation in Patients with Chronic Low Back Pain: An Open Label, Single Arm Clinical Trial.
Direct effect on back pain
We sought to understand the role of vitamin D3 supplementation in alleviating chronic low back pain (CLBP). In a single-arm, open-label study at a tertiary care hospital, we worked with 68 patients suffering from CLBP for at least three months, each demonstrating a significant pain level on a visual scale alongside low vitamin D levels.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Participants received 60,000 IU of vitamin D3 weekly for eight weeks. We tracked pain intensity and functional disability at various stages: at the outset, and then at two, three, and six months post-supplementation. Notably, we witnessed a remarkable increase in vitamin D levels from an average of 12.8 ng/mL to 36.07 ng/mL in those eight weeks, with 66% of participants achieving normal vitamin D levels.
The benefits didn’t stop there. Patients reported a significant drop in their pain scores at all follow-up periods, improving from 81 to 36 on the scale. Functional ability also saw enhancement over time, proving the positive influence of vitamin D3 on both pain and everyday activities.
Overall, our findings suggest that vitamin D3 supplementation can be an effective avenue for improving pain intensity and functionality in individuals with low back pain, warranting further investigation through controlled clinical trials.
Read More
9
Vitamin D aids musculoskeletal pain relief
A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain.
General relevance to musculoskeletal pain
We investigated the impact of adding 4000 IU of vitamin D3 on managing musculoskeletal pain, which includes back pain. In our study, we designed a randomized, double-blind, placebo-controlled trial involving 80 patients over three months. Each participant received either the vitamin D supplement or a placebo while their pain levels were monitored.
Our findings revealed that the group taking vitamin D experienced greater improvements in their pain levels, as measured by the Visual Analogue Scale (VAS). Notably, they reported a significant decline in pain compared to those receiving the placebo. Additionally, the need for rescue analgesics was markedly reduced among patients receiving vitamin D.
We also observed interesting changes in inflammatory markers. Specifically, levels of tumor necrosis factor alpha (TNFα) and prostaglandin E2 (PGE2) dropped significantly in the vitamin D group, indicating less inflammation compared to the placebo group, which actually saw increases in these markers.
In conclusion, incorporating a high dose of vitamin D may provide relief for those suffering from musculoskeletal pain, potentially through its effects on inflammation and pain perception.
Our findings revealed that the group taking vitamin D experienced greater improvements in their pain levels, as measured by the Visual Analogue Scale (VAS). Notably, they reported a significant decline in pain compared to those receiving the placebo. Additionally, the need for rescue analgesics was markedly reduced among patients receiving vitamin D.
We also observed interesting changes in inflammatory markers. Specifically, levels of tumor necrosis factor alpha (TNFα) and prostaglandin E2 (PGE2) dropped significantly in the vitamin D group, indicating less inflammation compared to the placebo group, which actually saw increases in these markers.
In conclusion, incorporating a high dose of vitamin D may provide relief for those suffering from musculoskeletal pain, potentially through its effects on inflammation and pain perception.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 26 Reviews
9
9.5
Reduced back pain
I recommend this to anyone lacking calcium. The price-to-quality ratio is good, and I did not experience any aftertaste or side effects. My back pain has significantly decreased in the morning, especially with my osteochondrosis.
9.5
Back pain relief
I ordered this calcium supplement on a whim due to the price. To my surprise, after two weeks, my shoulder pain, from which I suffered greatly, disappeared, even with arthrosis. I highly recommend it; it truly works!
9.5
Back pain relief
This has helped my 67-year-old mother with her osteochondrosis. After three months, her back pain improved significantly. We are very pleased and will continue taking this supplement.
9.5
Joint pain relief
After completing a course of this calcium, my joint pains vanished, and my teeth have become stronger. I'm thrilled with the results, as the calcium citrate absorbed well without causing any discomfort.
9.5
Pain reduction
My mother suffered from severe leg pain due to osteoporosis. After giving her these tablets, her pain significantly decreased within a week. I am very satisfied with this product's effectiveness.
